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Articles from Thomas Schmitt | Selfgrowth.com
- What Are Natural Phospholipids? - by Submitted on Jul 27, 2021 from Thomas SchmittLipids are defined as apolar molecules comprising as major classes fatty acids and fatty acid esters of normally natural origin. Non-natural components, such as dicarba-closo-dodecaboranes (in short carboranes) can also form acids and esters, which reveal lipid-like properties. Phospholipids are ...
Views: 405(1 vote) - Why Use CRISPR/Cas9 Antibodies? - by Submitted on Mar 30, 2019 from Thomas SchmittThe CRISPR-Cas9 system has proven to be a powerful tool for genome editing, allowing for the precise modification of specific DNA sequences within a cell. Many efforts are currently underway to use the CRISPR-Cas9 system for the therapeutic correction of human genetic diseases. The best ...
Views: 715(1 vote) - How Important Fungal Antigens Test Are - by Submitted on Mar 30, 2019 from Thomas SchmittFungus is the member in a big group which are made by eukaryotic organisms containing microorganisms. Most of them are not detrimental to human body, but some will lead to fungal disease. The reason is that biological compounds will be produced by fungi and some of compounds are harmful to ...
Views: 634(1 vote) - What Are Monomers? - by Submitted on Sep 30, 2021 from Thomas SchmittMonomers are molecules that can react together with other monomer molecules to form a larger polymer chain or three-dimensional network in a process called polymerization. There are mainly four types of monomers, including sugars, amino acids, fatty acids, and nucleotides, and each of these ...
Views: 540 - "Magic Bullet" in Precision Treatment of Tumors: Antibody Drug Conjugates (ADC Drugs) - by Submitted on Mar 26, 2025 from Thomas SchmittThe History of ADC Drugs ADC drug history begins with "magic bullet". Physicians have long had high cytotoxic chemotherapy drugs for tumour treatment. As they target cancer cells, chemotherapeutics will also random attack healthy cells and become systemically toxic. Paul Ehrlich came up with ...
Views: 20 - A Brief Description of Porcine Reproductive and Respiratory Syndrome Virus - by Submitted on Nov 28, 2022 from Thomas SchmittPorcine Reproductive and Respiratory Syndrome Virus (PRRSV) belongs to the Arteriviridae family and belongs to the Arterivirus. PRRSV can be divided into type I (PRRSV type I) and type II (PRRSV type II). The main clinical symptoms are abortion, stillbirth and mummified fetus of pregnant sows, ...
Views: 241 - A Fascinating Behind-the-Scenes Look at Electroluminescent Quantum Dots - by Submitted on Dec 31, 2020 from Thomas SchmittWhat are quantum dots? Quantum dots(QDs) are tiny particles in crystalline semiconductor materials, with sizes of a few nm, usually 2-10 nanometers in diameter. This is the size of a large molecule, although it’s smaller than DNA. They’re usually made up of hundreds or thousands of atoms in a ...
Views: 540 - A Few Tips To Better Know About Neutral Lipids - by Submitted on Jan 05, 2022 from Thomas SchmittWhat Are Neutral Lipids? Neutral lipids are defined as hydrophobic molecules lacking charged groups. Neutral lipids, such as cholesteryl ester (CE), triacylglycerol (TAG), and wax ester (WE), provide organisms with inert forms of energy used in conditions of nutrient deprivation and ...
Views: 331 - A Non-invasive Test for Detecting and Locating Cancer Cells - by Submitted on Mar 03, 2023 from Thomas SchmittWhen diagnosing cancer, most of the tests used by doctors (such as mammography, colonoscopy, and CT scans) are based on imaging. Engineers at the Massachusetts Institute of Technology have now created new diagnostic nanoparticles that can be used to monitor tumor recurrence after treatment or to ...
Views: 293 - A Quick Review of Cell Isolation & Organelles Isolation - by Submitted on Sep 22, 2021 from Thomas SchmittWhat is organelles isolation? The separation of organelles is achieved by cell membrane lysis and density gradient centrifugation to separate organelles from contaminated cell structures. The intact nucleus and organelles have a unique size in mammalian cells, allowing them to be separated by ...
Views: 385 - A Review of Proteolytic Targeting Chimeras - by Submitted on Apr 03, 2023 from Thomas SchmittThe concept of proteolytic targeting chimera (PROTAC) was first proposed by Crews and Deshaies laboratory in 2001, the team successfully achieved the degradation of methionyl aminopeptidase 2 (MetAp-2) by PROTAC method. Since then, PROTACs targeting androgen receptor (AR) and estrogen receptor ...
Views: 324 - A Short Biography of Carbon Dots - by Submitted on Jun 28, 2023 from Thomas SchmittCarbon dots (CDs) are a new type of zero-dimensional fluorescent nanomaterials with a size of less than 10 nm, which are composed of a graphitized sp2 carbon core and a shell containing abundant groups such as amino groups, ether groups, carbonyl groups, and hydroxyl groups on the surface, has ...
Views: 283 - Adeno-Associated Virus Vector (AAV) Application Q&A - by Submitted on May 29, 2024 from Thomas SchmittAdeno-associated virus (AAV), as an important gene delivery and expression tool, has been widely used in the fields of scientific research and gene therapy in recent years. As a gene delivery system, AAV viral vectors have the advantages of good safety, low immunogenicity, the ability to infect ...
Views: 209 - Advances in Research on Iron Oxide Nanoparticles to Amplify Tumor Imaging Signals - by Submitted on Aug 18, 2023 from Thomas SchmittIron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. They have shown a wide range of application prospects in the fields of sensor detection, disease diagnosis, gene therapy vectors, and targeted drug delivery. Recently, a research team has ...
Views: 281 - Advantages and Disadvantages of Nucleic Acid Aptamers - by Submitted on Sep 25, 2024 from Thomas SchmittNucleic acid aptamers are single-stranded oligonucleotides with the ability to specifically bind to target molecules. Currently, nucleic acid aptamers are screened from large random nucleic acid libraries using SELEX technology. It can identify different types of target molecules such as ...
Views: 133 - Advantages of Liposomal in Drug Delivery - by Submitted on Nov 29, 2022 from Thomas SchmittLiposomes are ultra-micro spherical carrier preparations formed by lipid bilayers, and are typical representatives of nano-drug delivery systems. When amphiphilic molecules such as phospholipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules gather together, and the ...
Views: 319 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 19, 2021 from Thomas Schmittanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 323 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 19, 2021 from Thomas SchmittNanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 342 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 23, 2021 from Thomas SchmittNanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 406 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 23, 2021 from Thomas SchmittNanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 412 - African Swine Fever Virus Detection Method - by Submitted on Oct 31, 2022 from Thomas SchmittAfrican swine fever(ASF) is a contagious infectious disease caused by African swine fever virus (ASFV) that spreads only among domestic pigs and wild boars, with a rapid onset, short course of disease, and a fatality rate of 100%. This article summarizes the latest progress in the detection ...
Views: 300 - Alzheimer's Disease Diagnostic Markers - by Submitted on Jan 23, 2024 from Thomas SchmittAlzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset. Clinically, it is characterized by comprehensive dementia manifestations such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality ...
Views: 254 - An Overview of Circulating Tumor DNA - by Submitted on Jun 02, 2019 from Thomas SchmittCirculating tumor DNA (ctDNA) is a kind of free DNA released by tumor cells after necrosis and apoptosis. Because it circulates in the blood, the detection of ctDNA can reflect the tumor state in time. In 1940, Mandel and Métais first discovered the presence of free cellular nucleic acids in the ...
Views: 498 - An Overview of Research on Human Metapneumovirus Infection - by Submitted on Jul 16, 2023 from Thomas SchmittRespiratory tract infection is an important cause of human morbidity and death worldwide and one of the main causes of death in children under 5 years old. Since 2001, researchers in the Netherlands reported a new virus related to respiratory tract infections in humans, especially infants – ...
Views: 286 - Antibody Heavy and Light Chains - by Submitted on Aug 18, 2021 from Thomas SchmittThe structure of all immunoglobulins is basically the same, consisting of two heavy chains (Heavy, abbreviated as H) and two light chains (Light, abbreviated as L), and looks like a “Y”-shaped symmetrical macromolecule. The stem of “Y” is called the Fc segment, which consists of the -COOH group ...
Views: 418 - Antibody-Immunoglobulin - by Submitted on May 08, 2023 from Thomas SchmittAntibody, also called Immunoglobulin, is a large Y globulin secreted by Effector B cell which is used in identifying and neutralizing the outsiders like bacterial and virus. Antibody is only found in blood ,body fluid and cytomembrane’s surface of Vertebrate. In addition, antiboy can identify ...
Views: 295 - Application of 3D Printing Bioinks Tissue Repair and Regenerative Medicine - by Submitted on Dec 26, 2023 from Thomas SchmittIntroduction to 3D Printing In the 1980s, American engineer Charles Hull developed rapid prototyping technology by combining points and surfaces and then using light reinforcement. After numerous failures, he finally invented stereolithography technology. Based on this technology, the world’s ...
Views: 286 - Application of Nanoparticles in CRISPR/Cas9 Gene Therapy - by Submitted on Jul 26, 2024 from Thomas SchmittAt present, genetic diseases are a large category of diseases that affect human health. So far, we can only treat a small part of them, and most of the treatment methods are "treating the symptoms but not the root cause". Therefore, gene therapy that can "cure the root cause" is highly ...
Views: 186 - Application of Polyethylene Glycol (PEG) in the Medical Field - by Submitted on Jan 27, 2022 from Thomas SchmittThe chemical structure of polyethylene glycol (PEG) is HO-(CH2CH2)n-OH, which is a general term for ethylene glycol polymers with a relative molecular mass of 200 to 8000 and above. Polyethylene glycol is the polymer with the lowest level of absorption by proteins and cells among the known ...
Views: 358 - Application of Transfersomes and Ethosomes in Transdermal Drug Delivery - by Submitted on Jun 01, 2021 from Thomas Schmitthe transfersomes is a self-aggregating vesicle obtained by formulating and improving on the basis of liposomes, also known as flexible nano-liposomes (FNL). It is a lipid carrier obtained by adding surfactants (such as sodium cholate, polysorbate, spaan, sodium deoxycholate, etc.) to liposome ...
Views: 285 - Application Research of Natural Hirudin - by Submitted on Mar 23, 2022 from Thomas SchmittHirudin is one of the most significant and most studied active ingredients in leeches and their salivary glands. It is a small molecule protein (polypeptide). Leeches are rich in hirudin, which has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin ...
Views: 337 - As the Key Player in Sunscreen, Is Titanium Dioxide Safe or Not? - by Submitted on Nov 26, 2024 from Thomas SchmittOn February 18, 2020, the European Commission finally included respirable titanium dioxide as a suspected carcinogen (category 2) based on a 2017 proposal. So, what is titanium dioxide? How does it affect our lives? Titanium dioxide, also known as titania, has been active in our daily life ...
Views: 96 - Autoimmune Diseases and Their Detection - by Submitted on Jun 28, 2024 from Thomas SchmittAutoimmune diseases are diseases caused by an autoimmune response. The role of the human immune system is to protect the body from pathogenic microorganisms and cancer cells. When the immune system accidentally attacks your body instead of protecting it, it will cause damage or dysfunction of ...
Views: 190 - B Cell Immunophenotyping - by Submitted on Dec 16, 2019 from Thomas Schmitt1.The background of B cells B lymphocytes, abbreviated as B cells, are differentiated from hematopoietic stem cells in the bone marrow. Most of the B cells that exert effector function live in the body for a short period of time, only a few days to several weeks, but their memory cells can ...
Views: 623 - Behind the Scenes of New Coronavirus Pneumonia-2019-nCov - by Submitted on Mar 17, 2020 from Thomas SchmittWhat is Novel Coronavirus? Novel Coronavirus (2019-nCoV) that was first detected in Wuhan City, Hubei Province, China and which continues to expand. Chinese health officials have reported thousands of infections with 2019-nCoV in China, with the virus reportedly spreading from ...
Views: 490 - Breakthrough Ideas for Parkinson’s Disease Treatment - by Submitted on Feb 01, 2023 from Thomas SchmittParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by bilateral motor (eg, bradykinesia, resting tremor, postural instability, rigidity) and nonmotor (eg, memory loss, depression) disability. About 10 million people worldwide suffer from Parkinson’s disease. ...
Views: 280 - Bridging the Gap: Evaluating HBV Vaccine Efficacy in Animal Models - by Submitted on Jan 20, 2025 from Thomas SchmittHepatitis B is a potentially deadly liver disease transmitted by the virus of hepatitis B (HBV). Globally, 2 billion people have contracted hepatitis B, according to WHO estimates, and approximately 1.5 million people get hepatitis B each year; the combined figure equals 800,000 deaths annually, ...
Views: 60 - Calprotectin in Inflammatory Diseases - by Submitted on May 28, 2023 from Thomas SchmittInflammation is an important defense response of the body that can control and clear various endogenous or exogenous damaging factors acting on the body, and also has a role in repairing damage. However, excessive or persistent inflammation can also cause damage to tissues and organs. ...
Views: 294 - Can PIVKA-II be Used in Liver Cell Cancer Research? - by Submitted on Aug 18, 2023 from Thomas SchmittHepatocellular cancer (HCC) is a clinically common malignant tumor of the digestive tract, which is seriously harmful to human health, and according to the survey, liver cancer accounts for the fifth largest incidence of tumors worldwide and the third mortality rate. At present, liver cancer in ...
Views: 303 - Cancer Target: Mesothelin - by Submitted on Feb 01, 2023 from Thomas SchmittMesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. Its biological function has not yet been clarified, but due to its limited distribution in normal tissues and high expression in some tumor tissues, it is expected to be used in tumor-specific treatment. In ...
Views: 328 - Carrageenans as a Versatile Tool in Drug Delivery - by Submitted on May 08, 2023 from Thomas SchmittDrug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the ...
Views: 323 - CdSe Quantum Dots You Don’t Want to Miss - by Submitted on Apr 25, 2022 from Thomas SchmittQuantum dots (QDs) are semiconductor nanoparticles which exhibit size and composition-dependent optical and electronic (optoelectronic) properties. QDs are ultrasmall, typically falling in the size range between 1.5 and 10.0 nm. QDs are new types of fluorescent materials for biological labeling. ...
Views: 301 - Chemical Medicine Lung Inhalation Nano Preparation - by Submitted on Dec 02, 2021 from Thomas SchmittAt present, a variety of chemical drugs are combined with nano-carriers to make lung-inhaled nano-preparations, and have achieved good results, such as anti-tuberculosis drugs, itraconazole, terbutaline sulfate, ciprofloxacin, curcumin and Camptothecin. Anti-tuberculosis drugs Polylactic ...
Views: 364 - Colored Polystyrene Particles in Developing Rapid and Affordable Point-of-Care Diagnostics - by Submitted on Apr 25, 2024 from Thomas SchmittPOCT (Point-of-Care Testing) refers to clinical and bedside testing conducted in close proximity to patients. It is often not performed by clinical laboratory personnel. POCT holds significant importance in disease prevention, etiology determination, prognosis, enhancing treatment outcomes, and ...
Views: 199 - Contrast Agents for Near-Infrared Fluorescent Imaging - by Submitted on Dec 02, 2021 from Thomas SchmittWhat is near-infrared fluorescence imaging? Near-infrared (NIR) fluorescence is a light wavelength of 650–950 nm and is generally preferred for in vivo fluorescence imaging because of its good tissue penetration and low autofluorescence from 676565adjacent tissues. NIR fluorescence imaging is ...
Views: 395 - Detection of Impurities Related to Biopharmaceutical Processes - by Submitted on Mar 03, 2023 from Thomas SchmittBiopharmaceutical impurities can be divided into two categories: extraneous contaminants and product-related impurities. Extraneous contaminants include microbial contamination, pyrogens, cellular components, components in culture media, substances from various steps in the production process, ...
Views: 256 - Difficulties in Research and Development of the Novel Coronavirus Vaccine - by Submitted on Feb 04, 2021 from Thomas SchmittAt present, the outbreak of COVID-19 has spread to more than 200 countries and regions around the world, and the number of confirmed cases has exceeded 6 million. The world is racing to develop the Novel Coronavirus vaccine. Dozens of candidate vaccines are undergoing pre-clinical evaluation, ...
Views: 341 - Do You Need Gold Nanostars? - by Submitted on Jan 20, 2025 from Thomas SchmittOver the past few years, gold nanostars have gained significant relevance in biology and medicine, in particular, in imaging and photothermal therapy, also owing to their biocompatibility. Furthermore, they have improved the sensitivity of diagnostic assays and have been integrated in ...
Views: 64 - Effects of Glucagon-Like Peptide-1 Receptor Agonists on Diabetic Cardiomyopathy - by Submitted on Feb 27, 2024 from Thomas SchmittThe incidence and prevalence of diabetes are increasing year by year globally, and patients with diabetes are at increased risk of cardiovascular disease and heart failure. Diabetic cardiomyopathy (DCM) refers to the presence of abnormal myocardial structure and performance in the absence of ...
Views: 223 - Exercise And Fasting Help Cells Clear Defective Proteins - by Submitted on Mar 17, 2020 from Thomas SchmittFailure of a cell’s protein processing mechanism can lead to the accumulation of misfolded proteins, which can block cells, interfere with their function, and accelerate the development of diseases over time, including neurodegenerative diseases, amyotrophic lateral sclerosis And Alzheimer’s. In ...
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