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Articles from Thomas Schmitt | Selfgrowth.com
- Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jun 28, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 198 - Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jul 25, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 172 - Research Finds Antibodies Show Promise for Treatment of Hantavirus - by Submitted on May 24, 2022 from Thomas SchmittAn international team of researchers has discovered the first human antibody that effectively neutralizes two types of hantaviruses in animal models, according to a study published online in the journal Science Translational Medicine. Based on their preliminary results, the antibody appears to ...
Views: 287 - Research of Cell Membrane Nano Drug Delivery System and Its Application in Bionic Nanomedicine - by Submitted on Jan 20, 2025 from Thomas SchmittMost of the old drugs are currently limited in their effectiveness because of poor pharmacokinetics, simple clearance by the body and cytotoxicity. Nanoparticle technology in particular, Nano drug delivery system is getting a lot of attention and application in medicine in the recent years. ...
Views: 63 - Research on Autoimmune Hemolytic Anemia - by Submitted on Nov 26, 2024 from Thomas SchmittAutoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia caused by the production of anti-self-erythrocyte antibodies due to immune dysfunction, binding to red blood cell surface antigens, or activating complement to accelerate the destruction of red blood cells. According to reports, ...
Views: 89 - Research on Capsular Polysaccharide Protein Conjugate Vaccine of Streptococcus Pneumoniae - by Submitted on Nov 27, 2023 from Thomas SchmittStreptococcus pneumoniae is a class of Gram-positive pathogenic bacteria that was first isolated in 1881. The chemical composition of the mucus layer on the surface of Streptococcus pneumoniae is a polysaccharide capsule, which is the main pathogenic substance of Streptococcus pneumoniae and has ...
Views: 286 - Research on Chimeric Antigen Receptor-Mediated Anti-Tumor Cell Therapy - by Submitted on Sep 25, 2024 from Thomas SchmittOver the past few decades, anti-tumor treatment has gradually evolved from traditional surgical resection, radiotherapy and chemotherapy to more precise molecularly targeted therapy and immunotherapy. These advances have improved the treatment of certain tumors to a certain extent. However, ...
Views: 138 - Research on Genetically Engineered Drug Host Cell Proteins - by Submitted on Feb 27, 2024 from Thomas SchmittGenetically engineered drugs are introduced into host cells such as Escherichia coli, yeast or mammalian cells through recombinant technology to construct engineering strains or cell strains, and then undergo specific expression, assembly, folding and post-translational modification processes to ...
Views: 241 - Research on Metal Nanoclusters in the Field of Biomedicine - by Submitted on Mar 26, 2022 from Thomas SchmittDue to the excellent characteristics of metal nanoclusters, they have many applications in the field of biomedicine. Current research shows that metal nanoclusters have good application value in biosensors, nucleic acid and protein molecular detection. Application of Metal Nanoclusters in ...
Views: 262 - Research on Platelet Drug Delivery System - by Submitted on Mar 26, 2025 from Thomas SchmittThe main focus of drug carrier research today is to identify carriers that are both safe and effective for clinical treatment applications. As treatment strategies advance researchers regularly update drug delivery systems. Traditional drug delivery systems consist of liposomes and polymer ...
Views: 18 - Research on Regulating cAMP Pathway to Chronic Obstructive Pulmonary Disease - by Submitted on Jan 20, 2025 from Thomas SchmittThe world's chronic disease, chronic obstructive pulmonary disease (COPD), is among the most incredibly morbid and mortal. A relatively common, preventable and curable condition, COPD most often reflects itself in chronic breathing problems and airway obstruction. Its cause is elusive and not ...
Views: 57 - Research on Snake Venom Detection Methods - by Submitted on Apr 25, 2024 from Thomas SchmittSnake bites seriously threaten public health security in tropical and subtropical countries and regions. Due to the high mortality and disability rates caused by venomous snake bites, there are an estimated 1.8 to 2.7 million snake bites worldwide each year, with 81,000 to 138,000 related ...
Views: 218 - Research on the Application of Nanoformulation in Transdermal Drug Delivery System - by Submitted on Feb 27, 2024 from Thomas SchmittAs a promising systemic drug delivery method, transdermal drug delivery system (TDDS) is easier and more convenient to operate than traditional oral, intravenous and subcutaneous injection methods. It can improve patient compliance while also avoiding First-pass effect and drug side effects. As ...
Views: 246 - Research on the Biological Effects of GLP-2 - by Submitted on Mar 27, 2024 from Thomas SchmittGLP-2 (glucagon-likepeptide-2) was discovered and named by the Lilly Laboratory in the United States when cloning the proglucagon gene (PG). In 1996, Drucker et al. discovered that the active ingredient in proglucagon-derived peptide (PGDP) that promotes intestinal mucosal growth is GLP-2. Its ...
Views: 259 - Research Progress of Pectin and Its Medical Application - by Submitted on May 28, 2023 from Thomas SchmittPectin is a hydrophilic vegetable gum. Widely present in the fruits, roots, stems and leaves of higher plants, it is a component of the cell wall. The pectin ontent of different plants or different parts of the same plant varies greatly. So far, only a few plants with high pectin content have ...
Views: 296 - Research Progress of PROTAC in the Treatment of Malignant Tumors - by Submitted on Dec 27, 2022 from Thomas SchmittMalignant tumors are a major global public health problem, the leading cause of death in developing countries and the second leading cause of death in developed countries. Traditional treatment methods such as surgical resection, radiotherapy and chemotherapy have serious side effects on the ...
Views: 291 - Research Progress on the Immune Mechanism of Varicella-Zoster Virus - by Submitted on Jul 25, 2024 from Thomas SchmittVaricella-zoster virus (VZV) is a pathogen widely present in the global population, infecting more than 90% of the world’s population. VZV primary infection often occurs in childhood, which can cause chickenpox characterized by systemic vesicular eruptions, and after infection, it can remain ...
Views: 179 - Research Status of Virus Vaccines - by Submitted on Dec 27, 2022 from Thomas SchmittSince the discovery of cowpox inoculation to prevent smallpox in the 18th century, vaccines have become an important means for human beings to resist pathogen infection and prevent the occurrence of diseases. Although immunization has eliminated or controlled the spread and pathogenic hazards of ...
Views: 308 - Researchers Learn That Non-toxic Concentration of Silver Nanoparticles Can Antagonize Arsenic-induced Genotoxicity - by Submitted on Apr 01, 2021 from Thomas SchmittRecently, a research team found that non-toxic concentrations of silver nanoparticles can antagonize the genotoxicity induced by arsenic by reducing the bioaccumulation of heavy metal arsenic in mammalian cells and enhancing the anti-oxidant ability in the cells. Related research results were ...
Views: 390 - Researchers Stabilize the Collapsing Metal-organic Frameworks by Adding a Polymer - by Submitted on Apr 23, 2021 from Thomas SchmittHigh internal surface area is a highly sought after asset in material design, bringing metal-organic frameworks (MOFs) at the forefront of materials research. In fact, the main focus in this field is to create innovative methods to maximize the surface area of the MOF. Nevertheless, macroporous ...
Views: 323 - SARS-CoV-2 Magnetic Particles You Don’t Want Miss - by Submitted on Dec 31, 2020 from Thomas SchmittAt present, the COVID-19 pandemic is still spreading rapidly. According to Google’s real-time statistics, until November 24, 2020, there have been more than 61 million total cases worldwide and more than 1.4 million deaths globally. The outbreak of SARS-CoV-2 threatens the global medical system ...
Views: 439 - Staphylococcus aureus Enterotoxin B - by Submitted on Jun 13, 2022 from Thomas SchmittStaphylococcus aureus (S. aureus) is an important food-borne pathogen that causes food contamination and food poisoning. It is also a symbiont of human skin and mucous membranes. About 20% to 30% of healthy individuals carry Staphylococcus aureus. Animal foods are susceptible to Staphylococcus ...
Views: 399 - Staphylococcus Aureus Enterotoxin B Detection Method - by Submitted on Nov 27, 2023 from Thomas SchmittStaphylococcus aureus (S. aureus) is an important class of food-borne pathogens that cause food contamination and food poisoning, and is also a symbiont of human skin and mucous membranes. Studies have found that about 20%~30 % of healthy individuals carry Staphylococcus aureus. Animal foods are ...
Views: 237 - Study on Partial Glycoprotein of Feline Herpesvirus Type 1 - by Submitted on Apr 03, 2023 from Thomas SchmittFeline herpesvirus type 1 (FHV-1) can cause acute and highly contagious infectious diseases in cats, namely feline infectious rhinotracheitis. In 1958, FHV-1 was isolated and identified for the first time from kittens suffering from respiratory diseases in the United States by Crandell et al. ...
Views: 259 - Study on Recombinant Hirudin - by Submitted on Jun 13, 2022 from Thomas SchmittAlthough natural hirudin is in great demand in clinical and pharmaceutical research, it is not easy to obtain. With the gradual exhaustion of natural leech resources, the gap between supply and demand is expanding year by year. In order to alleviate the shortage of leech resources, researchers ...
Views: 319 - Sucrose Polymer Overview - by Submitted on Jul 20, 2022 from Thomas SchmittSucrose is a disaccharide with a unique structure. It is a non-reducing sugar formed by removing a molecule of water from the glycoside hydroxyl group of a molecule of α-D-(+)-glucopyranose and a molecule of β-D-(-)-fructofuranose. During the hydrolysis process, the specific optical rotation of ...
Views: 340 - Techniques for Nanoparticle Size Characterization - by Submitted on Sep 25, 2024 from Thomas SchmittParticle size is an important detection index for nano-pharmaceutical preparations. All nano-pharmaceutical preparations must be tested for particle size and particle size distribution, including nano-emulsion, nano-crystals, nano-particles, and nanoplex. There are many particle size measuring ...
Views: 138 - Testing for Respiratory Syncytial Virus - by Submitted on Apr 25, 2024 from Thomas SchmittRespiratory syncytial virus was isolated from the cold-like respiratory tract of chimpanzees in 1956. It is called respiratory syncytial virus because it causes the fusion of adjacent cells during cell culture and the formation of syncytial-like structures in the cells. According to different ...
Views: 204 - The Circadian Rhythm - by Submitted on Jul 08, 2019 from Thomas SchmittIn light-sensitive higher organisms, the biological clock is a set of functional systems formed by photoreceptor neurons, endocrine systems, and gene timing oscillation expression regulation. It enables the organism to form a rhythm of day and night from microscopic levels of gene expression, ...
Views: 604 - The Endoplasmic Reticulum Stress and Disease - by Submitted on Aug 08, 2019 from Thomas SchmittThe endoplasmic reticulum (ER) is a very important multi-functional organelle in eukaryotic cells. While completing the basic physiological functions, the endoplasmic reticulum becomes a pivotal platform for coordinated signal transduction with its large membrane structure. The endoplasmic ...
Views: 547 - The Function of Drug Coating - by Submitted on Oct 31, 2022 from Thomas SchmittCoating refers to the unit operation of applying a layer of outer coating material to the dry surface of the formulation. This coating material not only makes the product easier to identify, but even improves the pharmacokinetic properties of the drug by altering its release: ensuring that the ...
Views: 305 - The Intestinal Bacteria-AKK - by Submitted on Oct 09, 2019 from Thomas SchmittWhat creatures still live in our bodies? This problem seems simple, but our understanding is not clear for a long time in history. In recent years, researchers have successively isolated human symbiotic microbes, which actually constitute most of the cells in our body. In human daily activities, ...
Views: 606 - The Intestinal Bacteria-AKK - by Submitted on Nov 15, 2019 from Thomas SchmittWhat creatures still live in our bodies? This problem seems simple, but our understanding is not clear for a long time in history. In recent years, researchers have successively isolated human symbiotic microbes, which actually constitute most of the cells in our body. In human daily activities, ...
Views: 579 - The Life Cycle of Epstein-Barr Virus - by Submitted on Jul 20, 2022 from Thomas SchmittEpstein-Barr Virus (EBV) is a large enveloped virus of double-stranded DNA among the eight known herpesviruses. After EBV infection of cells, it accumulates in the nucleus, and there are two life cycles, with alternating phases of latency and lysis. EBV infection is associated with a variety of ...
Views: 311 - The Life Cycle of Epstein-Barr Virus - by Submitted on Jul 20, 2022 from Thomas SchmittEpstein-Barr Virus (EBV) is a large enveloped virus of double-stranded DNA among the eight known herpesviruses. After EBV infection of cells, it accumulates in the nucleus, and there are two life cycles, with alternating phases of latency and lysis. EBV infection is associated with a variety of ...
Views: 271 - The Lysosomal Storage Disease - by Submitted on Sep 07, 2019 from Thomas SchmittLysosomes are a membrane-bound organelle found in many animal cells. They are spherical vesicles containing hydrolases that break down many biomolecules. The pH of the lysosome in the range of 4.5 to 5.0 is optimal for the enzyme involved in the hydrolysis. Lysosomes perform waste treatment ...
Views: 489 - The Mechanism of Adverse Immune Reactions of LNP-mRNA - by Submitted on May 29, 2024 from Thomas SchmittMany clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to ...
Views: 194 - The New Mechanism of Aging To Promote Cancer - by Submitted on Apr 23, 2021 from Thomas SchmittAs we age, the body will accumulate “garbage” in the body during the process of converting food into energy. Clinical statistics have found that the risk of cancer and related mortality in humans increases significantly with age from the age of 65. Is it because the body’s “junk” substances ...
Views: 345 - The Potential Toxicological Effects of Microplastics (Polystyrene Particles) On Human - by Submitted on Jul 16, 2023 from Thomas SchmittMicroplastics (such as polystyrene particles), which are small plastic particles, films, fragments, pellets, and textile fibers, are the main carriers that cause environmental pollution. Microplastics, whose particle sizes range from a few microns to a few millimeters, are inhomogeneous plastic ...
Views: 272 - The Relationship Between Gangliosides and Nervous System Development - by Submitted on Sep 20, 2023 from Thomas SchmittGangliosides (GA) are a class of glycosphingolipids (GSLs) containing sialic acid, which are widely distributed in tissues and body fluids, and are most abundant in the nervous system, where their expression accounts for 10 % ~ 12% of the total lipids in nerve cell membranes. Gangliosides ...
Views: 282 - The Return of Bird Flu - by Submitted on Nov 28, 2022 from Thomas SchmittAccording to data from the European Food Safety Authority, the European Centre for Disease Prevention and Control and the EU Avian Influenza Reference Laboratory, large-scale bird flu has occurred in Europe since June in 2022, affecting 37 European countries, from Norway to Sri Lanka. The Valbar ...
Views: 299 - The Role of CXCR5/CXCL13 Axis in Tumors - by Submitted on Dec 26, 2023 from Thomas SchmittThe tumor microenvironment is composed of tumor cells and non-tumor cells (including fibroblasts, vascular and lymphatic endothelial cells, various immune cells) and extracellular components (such as extracellular matrix, cytokines, inflammatory factors, chemokines, etc.) in tumor tissues. ...
Views: 254 - The Role of Targeting p53 Signaling Pathway in Cancer Therapy - by Submitted on Dec 26, 2023 from Thomas SchmittAs a tumor suppressor, p53 is one of the most commonly mutated genes in human cancers. Due to its important role in tumor suppression, p53 has attracted great interest from researchers in drug development. As a transcription factor, p53 is directly or indirectly involved in regulating many ...
Views: 227 - The Role of Vitamin D in Anti-tumor I - by Submitted on Jul 26, 2024 from Thomas SchmittVitamin D is a fat-soluble vitamin that can be obtained from food. At the same time, cholesterol in the body can be oxidized to 7-deoxycholesterol, which is converted into vitamin D by ultraviolet radiation. It is the precursor of a powerful steroid hormone. It synthesizes biologically active ...
Views: 188 - The Switch to Burn Fat-IL-27 - by Submitted on Mar 23, 2022 from Thomas SchmittObesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive food intake or changes in the body’s metabolism lead to excessive accumulation of fat in the body, resulting in ...
Views: 366 - The Synthesis of Nanoparticles You Don't Want to Miss - by Submitted on Nov 01, 2021 from Thomas SchmittNanoparticle synthesis refers to methods for creating nanoparticles. Nanoparticles can be derived from larger molecules, or synthesized by ‘bottom-up’ methods that, for example, nucleate and grow particles from fine molecular distributions in liquid or vapour phase. Synthesis can also include ...
Views: 391 - The Tumor Treating Fields You Don't Know - by Submitted on Jul 08, 2019 from Thomas SchmittElectric field therapy is a non-invasive method of tumor treatment that uses alternating electric fields of specific frequency and intensity to selectively destroy mitosis in cancer cells. Electric field therapy can target proteins that are critical to the cancer cell cycle, leading to mitotic ...
Views: 614 - The Wonderful Relationship between Atrial Natriuretic Peptide and Immune Regulation - by Submitted on Mar 25, 2025 from Thomas SchmittThe primary function of atrial natriuretic peptide (ANP/a>) includes regulation of water and salt metabolism together with vascular volume which helps control blood pressure stability. Additionally, ANP manages endothelial cell permeability and counters the adrenal aldosterone system which ...
Views: 19 - Trace Detection of Antibiotic Impurities in Cell Culture - by Submitted on Jan 27, 2022 from Thomas SchmittImpurities derived from cell culture include but are not limited to inducers, antibiotics, serum and other media components. These impurities need to be tested and evaluated one by one using risk assessment and risk management methods. If there is a potential impact on product safety, the ...
Views: 404 - Transglutaminases in Medical Research - by Submitted on Mar 03, 2023 from Thomas SchmittTransglutaminase (TGase) is an enzyme that catalyzes the acyl transfer reaction. It uses the C-carboxamide group of the glutamine residue in the peptide bond as the acyl donor, and the E-amino group of the lysyl residue in the polypeptide chain as the acyl acceptor, forming intramolecular and ...
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